To investigate if it is possible by adding pegylated interferon injections to current oral treatment, or switching from oral anti-hepatitis B medication to only pegylated interferon injections, will lead to a better treatment outcome.


Eligibility Criteria:

Age 21 – 70 years old

Hepatitis B carrier ≥ 6 months

On any NA treatment (Lamivudine, Adefovir, Entecavir or Tenofovir) for ≥ 1 year

HBV DNA undetected at screening

No history of depression or psychiatric disease, autoimmune disease & cancer



All blood tests, urine test and study medications (Peg-interferon ONLY) will be provided to you at no cost. You will be responsible for the costs of your clinic consultation fees, radiology scans (e.g. ultrasound, fibroscan) and oral medications.