To determine whether peg-IFN injection is effective in achieving Hepatitis B surface antigen loss, which is considered by most doctors as a cure of hepatitis B; also reduce having risk of liver disease progression such as development of liver cancer.
Age 21 – 75 years old
Hepatitis B carrier ≥ 6 months
Not on any medication treatment before
No history of cirrhosis & cancer
HBeAg negative, HBV DNA < 2000 IU/ml at screening
No history of depression or psychiatric disease
There will also be transport reimbursement of SGD30 per visit provided as the follow-up visits are routine clinic visits for controls (Arm A) only.