To determine whether peg-IFN injection is effective in achieving Hepatitis B surface antigen loss, which is considered by most doctors as a cure of hepatitis B; also reduce having risk of liver disease progression such as development of liver cancer.


Eligibility Criteria:

Age 21 – 75 years old

Hepatitis B carrier ≥ 6 months

Not on any medication treatment before

No history of cirrhosis & cancer

HBeAg negative, HBV DNA < 2000 IU/ml at screening

No history of depression or psychiatric disease



Pegasys, the injection will be provided to you at no cost. All the costs of laboratory tests and study-related procedures will be covered under the study.
There will also be transport reimbursement of SGD30 per visit provided as the follow-up visits are routine clinic visits for controls (Arm A) only.